Milo is a town in Piscataquis County, settled in 1802 and incorporated on January 21, 1823 from the township T3 R7 NWP.

It was named for the famed Greek athlete Milo of Crotona by the son of the first settler, Theophilus Sargent, who survived his first winter alone as a 14-year old with the help of friendly Indians.

Milo village lies just north of the junction of the Sebec and Piscataquis Rivers. The Pleasant River flows south through the town from Brownville to join the Piscataquis.

Derby, on the east side of the Sebec River, is a service area for the Bangor and Aroostook Railroad.